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4a5a8940cfaed4c9cfd066173390b1dc | A randomized Phase III trial demonstrated noninferiority of APF530 500 mg SC ( granisetron 10 mg ) to intravenous palonosetron 0.25 mg in preventing CINV in patients receiving MEC or HEC in acute ( 0 - 24 hours ) and delayed ( 24 - 120 hours ) settings , with activity over 120 hours . | [
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] | [] | Biochronomer™ technology and the development of APF530, a sustained release formulation of granisetron. granisetron and other 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are first-line agents for preventing chemotherapy-induced nausea and vomiting (CINV). Current treatment guidelines prefer the longer-actin... | https://pubmed.ncbi.nlm.nih.gov/27186139/ | ### Instruction:
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ef4fb4cd54c88e22cd1b882061876c8d | Classical NSAIDs are still the most logical choice for agents that will slow the progression or delay the onset of AD and other neurodegenerative diseases despite failures of naproxen , celecoxib and rofecoxib in AD clinical trials . | [
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"start": 2... | [] | Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Inflammation is characteristic of a broad spectrum of neurodegenerative diseases. These include Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases, amyotrophic lateral sclerosis, a... | https://pubmed.ncbi.nlm.nih.gov/15974901/ | ### Instruction:
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f3c31f04fdf5a6a559c0fd215a4ebe4c | Between 1987 and 2003 , patients 18 years old were given adjuvant chemotherapy consisting of one of two ' paediatric ' regimens ( depending on the time of presentation ) and craniospinal local-boost radiotherapy : regimen A ( n = 12 ) , vincristine ( VCR ) , intrathecal and/or intravenous methotrexate and conventional ... | [
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Survival of adults treated for medulloblastoma using paediatric protocols. We ... |
7c1b48c4fded5536004f52b2f9c14572 | The US Food and Drug Administration ( FDA ) recommends that " concomitant use of drugs that inhibit CYP2C19 ( e.g. , omeprazole ) should be discouraged . " As the presence of PPIs and clopidogrel in plasma is short lived , separation by 12 - 20 h should in theory prevent competitive inhibition of CYP metabolism and min... | [
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7639b3ca6251f63f76d161da9c24f217 | Long-term overall- and progression-free survival after pentostatin , cyclophosphamide and rituximab therapy for indolent non-Hodgkin lymphoma . | [
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Long-term overall- and progression-free survival after pentostatin , cyclophos... |
70e681adca9791cf2e10d9bd14f4c430 | Once-weekly isoniazid and rifapentine for 3 months is a treatment option in persons with human immunodeficiency virus and latent tuberculosis infection . | [
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Cytokine-Mediated Systemic Adverse Drug Reactions in a Drug-Drug Interaction S... |
5e01b68299caff14016a31896c325af2 | We investigated the effects of these inhibitors on other anticancer drugs including docetaxel , vinblastine , doxorubicin , 10-Hydroxycamptothecin ( 10-HCPT ) and cisplatin and find that both inhibitors induces DU145-TxR cells to be more sensitive only to the microtubule-targeting drugs ( paclitaxel , docetaxel and vin... | [
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960105c5f66a50001d208fdbe4f96ccb | Group B : From January , 1976 to December , 1980 , 55 evaluable patients participated in a consecutive study that added Adriamycin ( doxorubicin ) and cyclophosphamide to the former induction regimen . | [
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] | [] | Comparison of two consecutive trials for treatment of childhood non-Hodgkin's lymphoma. Two consecutive trials for the treatment of childhood non-Hodgkin's lymphoma were evaluated, carried out by the same cooperative groups. Group A: From June, 1973 to December, 1975, 50 evaluable patients under 16 years of age partici... | https://pubmed.ncbi.nlm.nih.gov/6388820/ | ### Instruction:
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Comparison of two consecutive trials for treatment of childhood non-Hodgkin's ... |
db3dec1a94dc53bf5435039c482e060c | When given in repeated doses from 6 h on , 50 g followed by 12.5 g at 6-h intervals , charcoal shortened the serum half-life of amitriptyline by 20 % and that of nortriptyline by 35 % ( p less than 0.05 ) . | [
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Pharmacokinetics of amitriptyline influenced by oral charcoal and urine pH. Th... |
db0e74273491043a8d918e7ddae08e7d | The median overall survival time was 22.7 months in the docetaxel arm and 22.4 months in the paclitaxel arm . | [
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] | [] | A phase II randomized study of two taxanes and cisplatin for metastatic breast cancer after anthracycline: a final analysis. The purpose of the study is to compare two taxanes/cisplatin combinations for metastatic breast cancer in terms of time to disease progression, response rates and toxicity. ### methods Between Ap... | https://pubmed.ncbi.nlm.nih.gov/17172351/ | ### Instruction:
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A phase II randomized study of two taxanes and cisplatin for metastatic breast... |
faf0c9f77be3f3da48e14be921b759f0 | We hypothesized that Aurora A kinase ( AK ) contributes to castrate resistance in prostate cancer ( PCa ) and that inhibiting AK with alisertib can resensitize PCa cells to androgen receptor ( AR ) inhibitor abiraterone . | [
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A Phase I/II Study of the Investigational Drug Alisertib in Combination With A... |
64be1cf1b7842c1f1e561a1885ffcb34 | Tanespimycin plus trastuzumab is well tolerated and has antitumor activity in patients with HER-2 + breast cancer whose tumors have progressed during treatment with trastuzumab . | [
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Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and acti... |
259fcb11e8020d04ee63f8e43cb90c7a | It contains data on prophylaxis with mefloquine ( n = 48,264 ) , with chloroquine ( 6,752 ) , with chloroquine plus proguanil ( 19,727 ) , and with no prophylaxis ( 3,871 ) . | [
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Tolerability and Effectiveness of Malaria Chemoprophylaxis with Mefloquine or ... |
dd0068d9fba06a8e7c381728dd8e1029 | We hypothesized that the brain damage mitigating effect of mild hypothermia after cardiac arrest can be enhanced with thiopental loading , and even more so with the further addition of phenytoin and methylprednisolone . | [
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138ed4d659b783b0815a4433b59d0cff | Caspase-independent mechanisms , mainly based on increased oxidative stress , result from 2-methoxyestradiol , Artesunate , ascorbic acid , Dihydroartemisinin , Evodiamine , b-AP15 , VLX1570 , Erw-ASNase , and TAK-242 . | [
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5edd6b7bf1ec8e231328a5a83f5b82ae | This was a multi-center randomized , two-armed , double-blinded phase II study comparing cediranib plus gefitinib versus cediranib plus placebo in subjects with first relapse/first progression of glioblastoma following surgery and chemoradiotherapy . | [
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Multi-Center Randomized Phase II Study Comparing Cediranib plus Gefitinib with... |
aef35abee464e3a0075caeb3d70926f6 | This study aims to compare the biological , molecular , pharmacological , and clinical characteristics of these three treatment modalities for SARS-COV-2 infections , Chloroquine and Hydroxychloroquine , Convalescent Plasma , and Remdesivir . | [
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Biological, molecular and pharmacological characteristics of chloroquine, hydr... |
be6dfc402b0da5cb965fc0a6da145866 | Patients received a mean ( ±standard deviation ) of 8.8 ± 4.9 intravitreal bevacizumab injections prior to the switch to intravitreal ranibizumab . | [
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] | [] | Diabetic macular edema treated with ranibizumab following bevacizumab failure in Israel (DERBI study). To evaluate the outcome of second-line intravitreal ranibizumab treatment in eyes with diabetic macular edema having persistent edema following initial therapy with intravitreal bevacizumab. ### Methods Diabetic macul... | https://pubmed.ncbi.nlm.nih.gov/29916263/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Diabetic macular edema treated with ranibizumab following bevacizumab failure ... |
0a53b483acefa9c81b17bd994c27ddfd | Combinations of penicillin and streptomycin and penicillin and amikacin were synergistic only against those strains that were not highly resistant to streptomycin and kanamycin , respectively . | [
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] | Species-specific resistance to antimocrobial synergism in Streptococcus faecium and Streptococcus faecalis. Combinations of penicillin with various aminoglycosidic aminocyclitols were tested against a collection of clinical isolates of Streptococcus faecium in vitro and were used to treat endocarditis caused by S. faec... | https://pubmed.ncbi.nlm.nih.gov/113469/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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Species-specific resistance to antimocrobial synergism in Streptococcus faeciu... |
7d64d6b1c7e8c6d3edc29168ad6c4477 | Treatment with a combination chemotherapeutic regimen consisting of cyclophosphamide , vincristine , and dacarbazine for malignant paraganglioma with hepatic metastasis is reported . | [
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] | Combination chemotherapy for malignant paraganglioma. Treatment with a combination chemotherapeutic regimen consisting of cyclophosphamide , vincristine , and dacarbazine for malignant paraganglioma with hepatic metastasis is reported . A 51-year-old male presented with tumors in the retroperitoneal space and liver. T... | https://pubmed.ncbi.nlm.nih.gov/9058098/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Combination chemotherapy for malignant paraganglioma. Treatment with a combin... |
498f31d903df63cf2f948946a8ee5018 | The aim of this study was to evaluate the in vitro effect of single antibiotic ( ciprofloxacin , ceftazidime , or ampicillin ) treatment on adherence of Escherichia coli and Enterococcus to plastic stents . | [
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"star... | [] | In vitro evaluation of antibiotic prophylaxis in the prevention of biliary stent blockage. Bacterial adherence and biofilm formation are important factors in the blockage of biliary stents. Clinical studies with oral antibiotic prophylaxis to prevent stent blockage have produced conflicting results. The aim of this stu... | https://pubmed.ncbi.nlm.nih.gov/10699774/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
In vitro evaluation of antibiotic prophylaxis in the prevention of biliary ste... |
717f8a8c20069d19d917002e078901ef | Paclitaxel and docetaxel as single agents have yielded overall response rates of 7 % to 56 % , depending on whether the patients have received prior chemotherapy for metastatic disease . | [
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] | [] | Current and future perspectives in advanced bladder cancer: is there a new standard? The methotrexate/vinblastine/doxorubicin/cisplatin (MVAC) regimen has been the standard treatment in patients with locally advanced and metastatic urothelial cancer for the past 15 years. The minimal or moderate survival benefit-depend... | https://pubmed.ncbi.nlm.nih.gov/11894002/ | ### Instruction:
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Current and future perspectives in advanced bladder cancer: is there a new sta... |
a963d46b799a8ea638850359444188f9 | The most effective treatment regimens for advanced nonseminomatous testicular tumors employ vinblastine , CDDP and bleomycin and adjunctive surgery . | [
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] | [Preoperative chemotherapy of testicular cancer and Wilm's tumor]. Of the various urogenital malignancies, preoperative chemotherapy is most effective for testicular cancer and Wilms' tumor. The most effective treatment regimens for advanced nonseminomatous testicular tumors employ vinblastine , CDDP and bleomycin and ... | https://pubmed.ncbi.nlm.nih.gov/2581512/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
[Preoperative chemotherapy of testicular cancer and Wilm's tumor]. Of the vari... |
773651170795da523779ad0a4d8fdd24 | 27 patients suffering from disseminated carcinoma of the breast with at least two visceral metastases , and two had become resistant to conventional chemotherpy and hormones , received a combination of , in the present trial , vincristine followed by cyclophosphamide with 5-fluoro-uracil . | [
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] | [Chemotherapeutic combinations of mutually potentializing drugs. 1-Application to the treatment of breast cancers]. 27 patients suffering from disseminated carcinoma of the breast with at least two visceral metastases , and two had become resistant to conventional chemotherpy and hormones , received a combination of ,... | https://pubmed.ncbi.nlm.nih.gov/1129034/ | ### Instruction:
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[Chemotherapeutic combinations of mutually potentializing drugs. 1-Application... |
8a164fc8cdf186bd07aed353d735c00b | We previously demonstrated that the combination of oral estramustine ( 15 mg/kg/day ) and oral etoposide ( 50 mg/m2/day ) is effective first-line therapy for the treatment of hormone refractory prostate cancer . | [
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] | A phase II trial of oral estramustine and oral etoposide in hormone refractory prostate cancer. We previously demonstrated that the combination of oral estramustine ( 15 mg/kg/day ) and oral etoposide ( 50 mg/m2/day ) is effective first-line therapy for the treatment of hormone refractory prostate cancer . We initiate... | https://pubmed.ncbi.nlm.nih.gov/9301705/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
A phase II trial of oral estramustine and oral etoposide in hormone refractory... |
3065e65032c8537a0d4a53be07e8519a | Therapy consisted of bendamustine ( 70 mg/m(2 ) ) for 2 consecutive days every 28 days , and ofatumumab 300 mg on day 1 and 1000 mg on day 8 during the first cycle , and 1000 mg on day 1 subsequently . | [
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] | Bendamustine in combination with ofatumumab in relapsed or refractory chronic lymphocytic leukemia: a GIMEMA Multicenter Phase II Trial. We conducted a phase II, noncomparative, open-label, multicenter GIMEMA (Gruppo Italiano Malattie EMatologiche dell'Adulto) study (CLL0809) to assess the efficacy and safety of bendam... | https://pubmed.ncbi.nlm.nih.gov/24220274/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Bendamustine in combination with ofatumumab in relapsed or refractory chronic ... |
304fb876f9dfa960295aef5a6099c04b | All consecutive patients with advanced BTC received the GEMOX regimen in a setting outside a study : gemcitabine 1,000 mg/m(2 ) on day 1 , and oxaliplatin 100 mg/m(2 ) on day 2 , treatment repeated every 2 weeks until progression or unacceptable toxicity . | [
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] | Experience of gemcitabine plus oxaliplatin chemotherapy in patients with advanced biliary tract carcinoma. The combination gemcitabine-oxaliplatin (GEMOX) is frequently used in patients with advanced biliary tract carcinoma (BTC). However, this is only based on phase II studies performed in selected patients.We assesse... | https://pubmed.ncbi.nlm.nih.gov/20551640/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
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### Input:
Experience of gemcitabine plus oxaliplatin chemotherapy in patients with advan... |
70bd47165d708bee82beff55a73c29fc | Recent randomized controlled trials ( RCT ) have failed to demonstrate the efficacy of widely used therapies , such as rituximab plus intravenous immunoglobulin or proteasome inhibition ( bortezomib ) , reinforcing a great need for new therapeutic concepts . | [
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] | Clazakizumab in late antibody-mediated rejection: study protocol of a randomized controlled pilot trial. Late antibody-mediated rejection (ABMR) triggered by donor-specific antibodies (DSA) is a cardinal cause of kidney allograft dysfunction and loss. Diagnostic criteria for this rejection type are well established, bu... | https://pubmed.ncbi.nlm.nih.gov/30635033/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Clazakizumab in late antibody-mediated rejection: study protocol of a randomiz... |
42c1681f652cf35adf1ced53b97516f8 | The aim of this study was to find an experimental model of a donor-recipient rat strain combination that , under triple drug immunosuppressive treatment ( methylprednisolone , cyclosporine , and azathioprine ) , would develop chronic rejection within a few weeks . | [
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{
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] | An experimental model of chronic renal allograft rejection in the rat using triple drug immunosuppression. Chronic rejection is a major problem in renal transplantation. Various experimental models have been developed to study vasculopathy of chronic rejection. However, animal models resembling the clinical situation o... | https://pubmed.ncbi.nlm.nih.gov/9448142/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
An experimental model of chronic renal allograft rejection in the rat using tr... |
373bedaa15b826ea4c469e0ce2643608 | In FOLL05 trial , R-CHOP was compared with R-CVP ( cyclophosphamide , vincristine , prednisone ) and R-FM ( fludarabine , mitoxantrone ) . | [
{
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] | Rituximab and new regimens for indolent lymphoma: a brief update from 2012 ASCO Annual Meeting. Indolent lymphoma (IL), the second most common lymphoma, remains incurable with chemotherapy alone. While R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) remains the standard frontline regimen for ... | https://pubmed.ncbi.nlm.nih.gov/22913602/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Rituximab and new regimens for indolent lymphoma: a brief update from 2012 ASC... |
a4a83ba48665f39aac03658bbacb486b | All patients underwent 3 cycles of neoadjuvant gemcitabine , paclitaxel , and capecitabine . | [
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] | Direct percutaneous transhepatic portomesenteric venous stenting in management of locally advanced pancreatic cancer. Pancreatectomy with portal and/or superior mesenteric vein resection remains a controversial procedure because of high complexity and morbidity. Neoadjuvant chemotherapy has been shown to increase resec... | https://pubmed.ncbi.nlm.nih.gov/23608832/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Direct percutaneous transhepatic portomesenteric venous stenting in management... |
509f0b830dc248843856cc659af95634 | The aim of the present investigation was to study and characterize the effect of voriconazole on the fungicidal activity of amphotericin B. | [
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] | Characterization of the inhibitory effect of voriconazole on the fungicidal activity of amphotericin B against Candida albicans in an in vitro kinetic model. The aim of the present investigation was to study and characterize the effect of voriconazole on the fungicidal activity of amphotericin B. ### methods Four stra... | https://pubmed.ncbi.nlm.nih.gov/18408237/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Characterization of the inhibitory effect of voriconazole on the fungicidal ac... |
f9f7d99cac5550bbc464785cf3e3db64 | Dual Therapy with Aspirin and Cilostazol May Improve Platelet Aggregation in Noncardioembolic Stroke Patients : A Pilot Study . | [
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] | Dual Therapy with Aspirin and Cilostazol May Improve Platelet Aggregation in Noncardioembolic Stroke Patients : A Pilot Study . Objective Some previous studies have found clinical benefit of dual antiplatelet therapy with aspirin and cilostazol for prevention of secondary stroke, but the physiological mechanism involve... | https://pubmed.ncbi.nlm.nih.gov/28566591/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Dual Therapy with Aspirin and Cilostazol May Improve Platelet Aggregation in N... |
d9bc9e760dfd975a2703bfd8e7ef700e | Gemcitabine and vinorelbine have shown activity in the first-line setting . | [
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] | Gemcitabine and vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma. pemetrexed-cisplatin chemotherapy is the standard of care in the first-line treatment of unresectable malignant pleural mesothelioma (MPM). Second-line cytotoxic therapy is considered for a growing group of patients, but ... | https://pubmed.ncbi.nlm.nih.gov/18286536/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Gemcitabine and vinorelbine in pemetrexed-pretreated patients with malignant p... |
4dfb347a107d0cb265cbec52dc05280d | The combination of tenofovir disoproxil fumarate ( TDF ) plus emtricitabine ( FTC ) is used extensively to treat HIV infection and also has potent activity against hepatitis B virus ( HBV ) infection . | [
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] | Efficacy and tolerance of a combination of tenofovir disoproxil fumarate plus emtricitabine in patients with chronic hepatitis B: a European multicenter study. The combination of tenofovir disoproxil fumarate ( TDF ) plus emtricitabine ( FTC ) is used extensively to treat HIV infection and also has potent activity aga... | https://pubmed.ncbi.nlm.nih.gov/21767570/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Efficacy and tolerance of a combination of tenofovir disoproxil fumarate plus ... |
c9947a148118a7c7c0374ef9e7f3a915 | HRQOL was better in Japanese postmenopausal women treated with tamoxifen than those treated with exemestane or anastrozole . | [
{
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"start": 1... | [] | Health-related quality of life, psychological distress, and adverse events in postmenopausal women with breast cancer who receive tamoxifen, exemestane, or anastrozole as adjuvant endocrine therapy: National Surgical Adjuvant Study of Breast Cancer 04 (N-SAS BC 04). Health-related quality of life (HRQOL), symptoms of d... | https://pubmed.ncbi.nlm.nih.gov/22234519/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Health-related quality of life, psychological distress, and adverse events in ... |
250ab0e4ff2d5694d10eb236713fe562 | This was driven by the relative advantage of weight loss compared with rosiglitazone , glimepiride , and insulin glargine , and administration frequency compared with exenatide . | [
{
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{
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] | [] | Willingness to pay for diabetes drug therapy in type 2 diabetes patients: based on LEAD clinical programme results. The purpose of this study was to investigate the preferences of people with diabetes for liraglutide vs other glucose lowering drugs, based on outcomes of clinical trials. ### methods Willingness to pay (... | https://pubmed.ncbi.nlm.nih.gov/22853443/ | ### Instruction:
Given the context about compound efficacy for the given treatment mentioned within the input, mentioned the compounds
that can co-occur for the mentioned treatment
### Input:
Willingness to pay for diabetes drug therapy in type 2 diabetes patients: base... |
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