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factoid
Which thyroid hormone transporter is implicated in thyroid hormone resistance syndrome?
['TH monocarboxylate transporter 8 (MCT8) mutation is implicated in the TH resistance syndrome']
Hemizygous MCT8 mutations cuases TH resistance syndrome in males characterized by severe psychomotor retardation, known as the Allan-Herndon-Dudley syndrome (AHDS).
[ "http://www.ncbi.nlm.nih.gov/pubmed/23392090", "http://www.ncbi.nlm.nih.gov/pubmed/22986150", "http://www.ncbi.nlm.nih.gov/pubmed/21459689", "http://www.ncbi.nlm.nih.gov/pubmed/18940949", "http://www.ncbi.nlm.nih.gov/pubmed/17574009", "http://www.ncbi.nlm.nih.gov/pubmed/17161330", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/23392090", "endSection": "abstract", "offsetInBeginSection": 489, "offsetInEndSection": 732, "text": "Hemizygous MCT8 mutations in males cause severe psychomotor retardation, known as the Allan-Herndon-Dudley syndr...
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D018382", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D013963", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D037021", "http://www.nlm.nih.gov/cgi/mesh/2...
[]
52f8b2902059c6d71c000053
factoid
Name synonym of Acrokeratosis paraneoplastica.
[['Bazex syndrome']]
['Acrokeratosis paraneoplastic (Bazex syndrome) is a rare, but distinctive paraneoplastic dermatosis characterized by erythematosquamous lesions located at the acral sites and is most commonly associated with carcinomas of the upper aerodigestive tract.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/22252191", "http://www.ncbi.nlm.nih.gov/pubmed/22146896", "http://www.ncbi.nlm.nih.gov/pubmed/22470801", "http://www.ncbi.nlm.nih.gov/pubmed/18775590", "http://www.ncbi.nlm.nih.gov/pubmed/18672707", "http://www.ncbi.nlm.nih.gov/pubmed/17097409", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/22252191", "endSection": "abstract", "offsetInBeginSection": 0, "offsetInEndSection": 154, "text": "Acrokeratosis paraneoplastica of Bazex is a rare but important paraneoplastic dermatosis, usually manifesting as p...
5
BioASQ-training5b
[]
[]
56bc751eac7ad10019000013
factoid
Orteronel was developed for treatment of which cancer?
[['castration-resistant prostate cancer']]
['Orteronel was developed for treatment of castration-resistant prostate cancer.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/26150028", "http://www.ncbi.nlm.nih.gov/pubmed/25701170", "http://www.ncbi.nlm.nih.gov/pubmed/25624429", "http://www.ncbi.nlm.nih.gov/pubmed/25537627", "http://www.ncbi.nlm.nih.gov/pubmed/24799061", "http://www.ncbi.nlm.nih.gov/pubmed/25264242", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/26150028", "endSection": "abstract", "offsetInBeginSection": 225, "offsetInEndSection": 395, "text": "Pooled-analysis was also performed, to assess the effectiveness of agents targeting the androgen axis via identi...
5
BioASQ-training5b
[ "http://www.disease-ontology.org/api/metadata/DOID:162" ]
[]
56c1f01def6e394741000045
factoid
Which is the protein that is encoded by the gene GLT8D1?
[['glycosyltransferase 8 domain containing 1']]
['The GLT8D1 gene codes for the protein named glycosyltransferase 8 domain containing 1']
[ "http://www.ncbi.nlm.nih.gov/pubmed/24373612", "http://www.ncbi.nlm.nih.gov/pubmed/24114764" ]
[]
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016695", "http://www.uniprot.org/uniprot/GL8D1_BOVIN", "http://www.uniprot.org/uniprot/GL8D1_DANRE", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0016757" ]
[ { "o": "http://linkedlifedata.com/resource/#_43394A593936009", "p": "http://purl.uniprot.org/core/encodedBy", "s": "http://purl.uniprot.org/uniprot/C9JY96" }, { "o": "GLT8D1", "p": "http://www.w3.org/2004/02/skos/core#prefLabel", "s": "http://linkedlifedata.com/resource/#_43394A593936009...
54d643023706e89528000007
factoid
Where is the protein Pannexin1 located?
[['plasma membrane']]
['The protein Pannexin1 is localized to the plasma membranes.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/19409451", "http://www.ncbi.nlm.nih.gov/pubmed/17064878", "http://www.ncbi.nlm.nih.gov/pubmed/26100513", "http://www.ncbi.nlm.nih.gov/pubmed/24642372", "http://www.ncbi.nlm.nih.gov/pubmed/24694658", "http://www.ncbi.nlm.nih.gov/pubmed/25056878", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/19409451", "endSection": "abstract", "offsetInBeginSection": 394, "offsetInEndSection": 620, "text": "zfPanx1 was identified on the surface of horizontal cell dendrites invaginating deeply into the cone pedicle nea...
5
BioASQ-training5b
[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0051179" ]
[ { "o": "C544702", "p": "http://www.w3.org/2004/02/skos/core#notation", "s": "http://linkedlifedata.com/resource/umls/label/A17397470" }, { "o": "http://linkedlifedata.com/resource/umls/label/A17400569", "p": "http://linkedlifedata.com/resource/umls/altMetaMap", "s": "http://linkedlifedat...
56af9f130a360a5e45000015
factoid
What is the mode of inheritance of Wilson's disease?
['autosomal recessive']
Wilson's disease (WD) is an autosomal recessive disorder.
[ "http://www.ncbi.nlm.nih.gov/pubmed/16932613", "http://www.ncbi.nlm.nih.gov/pubmed/20662462", "http://www.ncbi.nlm.nih.gov/pubmed/22610954", "http://www.ncbi.nlm.nih.gov/pubmed/8615372", "http://www.ncbi.nlm.nih.gov/pubmed/12152840", "http://www.ncbi.nlm.nih.gov/pubmed/8186659", "http://www.ncbi.nlm.nih...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/16932613", "endSection": "abstract", "offsetInBeginSection": 122, "offsetInEndSection": 272, "text": "The disease has an autosomal recessive mode of inheritance, and is characterized by excessive copper deposition,...
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D006527", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014918", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D020739", "http://www.nlm.nih.gov/cgi/mesh/2...
[ { "o": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/1198", "p": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseasome/diseaseSubtypeOf", "s": "http://www4.wiwiss.fu-berlin.de/diseasome/resource/diseases/4181" }, { "o": "Wilson_disease", "p": "http://www4.wiwiss.fu-ber...
52bf1b0a03868f1b06000009
factoid
What is the mode of inheritance of Facioscapulohumeral muscular dystrophy (FSHD)?
['autosomal dominant']
Facioscapulohumeral muscular dystrophy has an autosomal dominant inheritance pattern.
[ "http://www.ncbi.nlm.nih.gov/pubmed/22551571", "http://www.ncbi.nlm.nih.gov/pubmed/22525183", "http://www.ncbi.nlm.nih.gov/pubmed/21795275", "http://www.ncbi.nlm.nih.gov/pubmed/19248726", "http://www.ncbi.nlm.nih.gov/pubmed/15307599", "http://www.ncbi.nlm.nih.gov/pubmed/10969520", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/23143600", "endSection": "abstract", "offsetInBeginSection": 214, "offsetInEndSection": 238, "text": "autosomal dominant FSHD1" }, { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/...
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D014918", "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D040582" ]
[]
52bf19c503868f1b06000001
factoid
What kind of chromatography is HILIC?
[['Hydrophilic Interaction Chromatography']]
['Hydrophilic Interaction Chromatography (HILIC)']
[ "http://www.ncbi.nlm.nih.gov/pubmed/23217321", "http://www.ncbi.nlm.nih.gov/pubmed/23073287", "http://www.ncbi.nlm.nih.gov/pubmed/22946920", "http://www.ncbi.nlm.nih.gov/pubmed/21737084", "http://www.ncbi.nlm.nih.gov/pubmed/21316059", "http://www.ncbi.nlm.nih.gov/pubmed/21238772" ]
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/23217321", "endSection": "abstract", "offsetInBeginSection": 2, "offsetInEndSection": 96, "text": "hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC LC-MS/MS) method" }, { "begin...
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D002845" ]
[]
5505edac8e1671127b000005
factoid
What is the structural fold of bromodomain proteins?
[['All-alpha-helical fold']]
['The structure fold of the bromodomains is an all-alpha-helical fold, which includes a left-handed four-helix bundle topology, with two short additional helices in a long connecting loop.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/17694091", "http://www.ncbi.nlm.nih.gov/pubmed/17848202", "http://www.ncbi.nlm.nih.gov/pubmed/17582821", "http://www.ncbi.nlm.nih.gov/pubmed/17148447", "http://www.ncbi.nlm.nih.gov/pubmed/17274598", "http://www.ncbi.nlm.nih.gov/pubmed/17498659", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/17694091", "endSection": "abstract", "offsetInBeginSection": 780, "offsetInEndSection": 1028, "text": "These new studies also support the notion that functional diversity of a conserved bromodomain structural fold ...
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2016/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011506" ]
[]
56e2cec751531f7e33000015
factoid
Which MAP kinase phosphorylates the transcription factor c-jun?
[['c-Jun NH2-terminal kinase', 'JNK']]
['c-Jun is phosphorylated by c-Jun NH2-terminal kinase (JNK).', 'An in vitro kinase assay revealed that c-Jun phosphorylation is primarily mediated via activated c-Jun N-terminal protein kinase (JNK).', 'c-Jun is phosphorylated by c-Jun NH2-terminal kinase (JNK).']
[ "http://www.ncbi.nlm.nih.gov/pubmed/24321566", "http://www.ncbi.nlm.nih.gov/pubmed/24321066", "http://www.ncbi.nlm.nih.gov/pubmed/24300195", "http://www.ncbi.nlm.nih.gov/pubmed/24291243", "http://www.ncbi.nlm.nih.gov/pubmed/24285252", "http://www.ncbi.nlm.nih.gov/pubmed/24272171", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/24321566", "endSection": "abstract", "offsetInBeginSection": 955, "offsetInEndSection": 987, "text": " c-Jun NH2-terminal kinase (JNK)" }, { "beginSection": "abstract", "document": "http://www.ncbi.nlm....
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D016755", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007258", "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=GO:0007257" ]
[]
5518e7da622b194345000004
factoid
What is the meaning of the acronym "TAILS" used in protein N-terminomics?
['TAILS: Terminal Amine Isotopic Labeling of Substrates']
TAILS stands for "Terminal Amine Isotopic Labeling of Substrates"
[ "http://www.ncbi.nlm.nih.gov/pubmed/23667905", "http://www.ncbi.nlm.nih.gov/pubmed/22577022", "http://www.ncbi.nlm.nih.gov/pubmed/22367194", "http://www.ncbi.nlm.nih.gov/pubmed/21604129", "http://www.ncbi.nlm.nih.gov/pubmed/20305284" ]
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/21604127", "endSection": "abstract", "offsetInBeginSection": 127, "offsetInEndSection": 305, "text": ". It is important to identify what proteins are substrates of proteases and where their cleavage sites are so as...
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2014/MB_cgi?field=uid&exact=Find+Exact+Term&term=D011506", "http://www.uniprot.org/uniprot/TERM_DROME" ]
[]
530a5117970c65fa6b000007
factoid
Which fusion protein is involved in the development of Ewing sarcoma?
[['EWS/FLI1']]
['Ewing sarcoma is the second most common bone malignancy in children and young adults. In almost 95% of the cases, it is driven by oncogenic fusion protein EWS/FLI1, which acts as an aberrant transcription factor, that upregulates or downregulates target genes, leading to cellular transformation.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/23750284", "http://www.ncbi.nlm.nih.gov/pubmed/17453169", "http://www.ncbi.nlm.nih.gov/pubmed/17250957", "http://www.ncbi.nlm.nih.gov/pubmed/22723308", "http://www.ncbi.nlm.nih.gov/pubmed/16206264", "http://www.ncbi.nlm.nih.gov/pubmed/25401475", "http://www.ncbi.nlm.n...
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/23750284", "endSection": "abstract", "offsetInBeginSection": 0, "offsetInEndSection": 266, "text": "Ewing sarcoma is the second most common bone malignancy in children and young adults. It is driven by oncogenic fu...
5
BioASQ-training5b
[ "http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&exact=Find+Exact+Term&term=D012512", "http://www.disease-ontology.org/api/metadata/DOID:3368", "http://www.disease-ontology.org/api/metadata/DOID:4980" ]
[]
552fac4fbc4f83e828000006
factoid
Treatment of which disease was investigated in the MR CLEAN study?
[['acute ischemic stroke']]
['Multicenter Randomized CLinical trial of Endovascular treatment for Acute ischemic stroke in the Netherlands (MR CLEAN) study investigated endovascular treatment for acute ischemic stroke.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/25517348", "http://www.ncbi.nlm.nih.gov/pubmed/25432979", "http://www.ncbi.nlm.nih.gov/pubmed/25179366", "http://www.ncbi.nlm.nih.gov/pubmed/24330796" ]
[ { "beginSection": "abstract", "document": "http://www.ncbi.nlm.nih.gov/pubmed/25432979", "endSection": "abstract", "offsetInBeginSection": 0, "offsetInEndSection": 303, "text": "INTRODUCTION: A recent randomized controlled trial (RCT), the Multicenter Randomized CLinical trial of Endovascula...
5
BioASQ-training5b
[]
[]
54cf7051f693c3b16b000013
factoid
Which enzyme is targeted by Evolocumab?
[['proprotein convertase subtilisin/kexin type 9']]
['Evolocumab (AMG145) is a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9) that demonstrated marked reductions in plasma low-density lipoprotein cholesterol concentrations in statin-intolerant patients.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/24661068", "http://www.ncbi.nlm.nih.gov/pubmed/24598985", "http://www.ncbi.nlm.nih.gov/pubmed/24509273", "http://www.ncbi.nlm.nih.gov/pubmed/24481874", "http://www.ncbi.nlm.nih.gov/pubmed/24477778", "http://www.ncbi.nlm.nih.gov/pubmed/24284914", "http://www.ncbi.nlm.n...
[ { "beginSection": "title", "document": "http://www.ncbi.nlm.nih.gov/pubmed/24661068", "endSection": "title", "offsetInBeginSection": 0, "offsetInEndSection": 162, "text": "Efficacy and safety profile of evolocumab (AMG145), an injectable inhibitor of the proprotein convertase subtilisin/kexi...
5
BioASQ-training5b
[]
[]
54e0d1491388e8454a000014
factoid
What is the methyl donor of DNA (cytosine-5)-methyltransferases?
['S-adenosyl-L-methionine']
['S-adenosyl-L-methionine (AdoMet, SAM) is the methyl donor of DNA (cytosine-5)-methyltransferases. DNA (cytosine-5)-methyltransferases catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the C-5 position of cytosine residues in DNA.']
[ "http://www.ncbi.nlm.nih.gov/pubmed/8441638", "http://www.ncbi.nlm.nih.gov/pubmed/11208790", "http://www.ncbi.nlm.nih.gov/pubmed/7607467", "http://www.ncbi.nlm.nih.gov/pubmed/8065896", "http://www.ncbi.nlm.nih.gov/pubmed/7578083", "http://www.ncbi.nlm.nih.gov/pubmed/1584813", "http://www.ncbi.nlm.nih.go...
[ { "beginSection": "sections.0", "document": "http://www.ncbi.nlm.nih.gov/pubmed/8441638", "endSection": "sections.0", "offsetInBeginSection": 0, "offsetInEndSection": 256, "text": "The product of the dcm gene is the only DNA cytosine-C5 methyltransferase of Escherichia coli K-12; it catalyse...
5
BioASQ-training5b
[ "http://amigo.geneontology.org/cgi-bin/amigo/term_details?term=0003886", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D004248", "http://www.nlm.nih.gov/cgi/mesh/2012/MB_cgi?field=uid&exact=Find+Exact+Term&term=D019175" ]
null
51404dd723fec90375000002
End of preview. Expand in Data Studio

BioASQ - All Question Types

A comprehensive collection of BioASQ challenge questions organized by question type as separate splits.

Purpose

This dataset is a convenience collection of BioASQ questions reformatted for easier use. The original source data is from the BioASQ Challenge. We created this reorganized version (with question types as splits) to facilitate evaluation in our PaperSearchQA work.

IMPORTANT: This is not the original BioASQ dataset. We have simply reorganized the BioASQ data into splits by question type. All underlying question and answer data is from BioASQ.

Dataset Description

This dataset contains 5,404 biomedical questions from the BioASQ challenge, distributed across four question types:

  • factoid (1,609 samples): Questions with short factual answers
  • yesno (1,464 samples): Yes/No questions
  • summary (1,283 samples): Questions requiring summarization
  • list (1,048 samples): Questions with list-based answers

Each question type is provided as a separate split for convenient filtering and evaluation.

Source and Attribution

Original Data Source: BioASQ Challenge

BioASQ is a series of challenges on large-scale biomedical semantic indexing and question answering.

IMPORTANT: To use BioASQ data, you must:

  1. Register at: https://bioasq.org/
  2. Review and comply with BioASQ terms of use
  3. Cite the BioASQ papers (see below)
  4. Acknowledge the BioASQ dataset in any publications

Dataset Structure

Data Fields

Each sample contains:

  • id: Unique question identifier
  • body: The question text
  • type: Question type (factoid, yesno, summary, or list)
  • ideal_answer: Reference answer(s)
  • exact_answer: Structured answer (for factoid/list questions)
  • documents: URLs of relevant PubMed documents
  • snippets: Relevant text snippets from the documents

Data Splits

The dataset is organized into 4 splits by question type:

Split Examples
factoid 1,609
yesno 1,464
summary 1,283
list 1,048
Total 5,404

Usage

from datasets import load_dataset

# Load all question types
dataset = load_dataset("jmhb/BioASQ")

# Load only factoid questions
factoid = load_dataset("jmhb/BioASQ", split="factoid")

# Load specific question types
dataset = load_dataset("jmhb/BioASQ", split=["factoid", "yesno"])

Citation

If you use this dataset, you must cite the original BioASQ papers (the first two below). If you found this processed version valuable, please also consider citing PaperSearchQA:

@article{krithara2023bioasq,
  title={BioASQ-QA: A manually curated corpus for Biomedical Question Answering},
  author={Krithara, Anastasia and Nentidis, Anastasios and Bougiatiotis, Konstantinos and Paliouras, Georgios},
  journal={Scientific Data},
  volume={10},
  number={1},
  pages={170},
  year={2023},
  publisher={Nature Publishing Group UK London}
}

@article{tsatsaronis2015overview,
  title={An overview of the BIOASQ large-scale biomedical semantic indexing and question answering competition},
  author={Tsatsaronis, George and Balikas, Georgios and Malakasiotis, Prodromos and Partalas, Ioannis and Zschunke, Matthias and Alvers, Michael R and Weissenborn, Dirk and Krithara, Anastasia and Petridis, Sergios and Polychronopoulos, Dimitris and others},
  journal={BMC bioinformatics},
  volume={16},
  number={1},
  pages={138},
  year={2015},
  publisher={Springer}
}

@misc{burgess2026papersearchqalearningsearchreason,
      title={PaperSearchQA: Learning to Search and Reason over Scientific Papers with RLVR},
      author={James Burgess and Jan N. Hansen and Duo Peng and Yuhui Zhang and Alejandro Lozano and Min Woo Sun and Emma Lundberg and Serena Yeung-Levy},
      year={2026},
      eprint={2601.18207},
      archivePrefix={arXiv},
      primaryClass={cs.LG},
      url={https://arxiv.org/abs/2601.18207},
}

License and Terms of Use

BioASQ License

The original BioASQ data is available for research and educational purposes under specific terms:

  • Non-commercial use: Freely available for academic research and education
  • Commercial use: Requires written permission from BioASQ organizers
  • Attribution: Must cite BioASQ papers and acknowledge the dataset
  • Registration: Users must register at https://bioasq.org/

For full license terms, see: https://bioasq.org/participate

This Dataset

This reorganized version is provided for research convenience. All terms and conditions of the original BioASQ license apply.

Links

Acknowledgments

This dataset is made available through the BioASQ Challenge organizers. We thank them for creating and maintaining this valuable resource for the biomedical NLP community.

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